Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells Metabolic stress, corresponding to lipotoxicity, impacts the DNA methylation profile in pancreatic β-cells and thus contributes to β-cell failure and the development of sort 2 diabetes (T2D). Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme that’s concerned in monounsaturated fatty acid synthesis, which protects pancreatic β-cells towards lipotoxicity. The current research discovered that SCD1 can also be required for the institution and upkeep of DNA … Continue reading „Circulating Vitamin D Levels and DNA Repair Capacity in Four Molecular“